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Article

Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.

Nature communications - 23 Feb 2021

Bianchi Enrica, Sun Yi, Almansa-Ordonez Alexandra, Woods Michael, Goulding David, Martinez-Martin Nadia, Wright Gavin J

Abstract excerpt

Dysfunction of embryo transport causes ectopic pregnancy which affects approximately 2% of conceptions in the US and Europe, and is the most common cause of pregnancy-related death in the first trimester. Embryo transit involves a valve-like tubal-locking phenomenon that temporarily arrests oocytes at the ampullary-isthmic junction (AIJ) where fertilisation occurs, but the mechanisms involved are unknown. Here we...

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Identifiers

PMID: 33623007
DOI: 10.1038/s41467-021-21512-w
PMCID: PMC7902839

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