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Leptin-elicited PBX3 confers letrozole resistance in breast cancer

19 Feb 2021

Abstract excerpt

Aberrant leptin signaling and overexpression of fibroblast growth factor receptor 1 (FGFR1) are both implicated in the pathogenesis of letrozole resistance in breast cancer (BCa), but it remains unknown whether these two pathways are involved in letrozole resistance in a coordinated manner. Here, we demonstrate that expression levels of the pre-B-cell leukemia homeobox transcription factor 3 (PBX3), a pioneer...

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PMID: 33608482
DOI: 10.1530/erc-20-0328

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