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Article

Leptin–STAT3–G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression

3 Apr 2015

Abstract excerpt

Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Here we report how leptin, an obesity-associated adipokine, regulates a transcriptional pathway to silence a genetic program of epithelial homeostasis in breast cancer stem-like cells (CSC) that promotes malignant progression. Using genome-wide ChIP-seq and RNA expression profiling, we defined a role for activated...

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PMID: 25840984
DOI: 10.1158/0008-5472.can-14-3076

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