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Epigenetic Age Acceleration and Cognitive Decline: A Twin Study

19 Feb 2021

Abstract excerpt

BACKGROUND: Little is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm age acceleration is related to cognitive decline measured longitudinally in persons without a clinical diagnosis of dementia. METHODS: We studied 266 paired male twins (133 pairs) with a mean age of 56 years at baseline. Of these, 114 paired...

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PMID: 33606025
DOI: 10.1093/gerona/glab047

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