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Article

Addressing Darwin's dilemma: Can pseudo-overdominance explain persistent inbreeding depression and load?

Evolution; international journal of organic evolution - 1 Apr 2021

Waller Donald M

Abstract excerpt

Darwin spent years investigating the effects of self-fertilization, concluding that "nature abhors perpetual self-fertilization." Given that selection purges inbred populations of strongly deleterious mutations and drift fixes mild mutations, why does inbreeding depression (ID) persist in highly inbred taxa and why do no purely selfing taxa exist? Background selection, associations and interference among loci,...

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PMID: 33598971
DOI: 10.1111/evo.14189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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