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Article

Tumor immunogenomic signatures improve a prognostic model of melanoma survival.

Journal of translational medicine - 17 Feb 2021

Morales Leah, Simpson Danny, Ferguson Robert, Cadley John, Esteva Eduardo, Monson Kelsey, Chat Vylyny, Martinez Carlos, Weber Jeffrey, Osman Iman, Kirchhoff Tomas

Abstract excerpt

BACKGROUND: Tumor mutation burden (TMB) has been associated with melanoma immunotherapy (IT) outcomes, including survival. We explored whether combining TMB with immunogenomic signatures recently identified by The Cancer Genome Atlas (TCGA) can refine melanoma prognostic models of overall survival (OS) in patients not treated by IT. METHODS: Cox proportional-hazards (Cox PH) analysis was performed on 278...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33596955
DOI: 10.1186/s12967-021-02738-0
PMCID: PMC7888085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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