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Article

The Goto-Kakizaki rat is a spontaneous prototypical rodent model of polycystic ovary syndrome.

Nature communications - 16 Feb 2021

Bourgneuf Camille, Bailbé Danielle, Lamazière Antonin, Dupont Charlotte, Moldes Marthe, Farabos Dominique, Roblot Natacha, Gauthier Camille, Mathieu d'Argent Emmanuelle, Cohen-Tannoudji Joelle, Monniaux Danielle, Fève Bruno, Movassat Jamileh, di Clemente Nathalie, Racine Chrystèle

Abstract excerpt

Polycystic ovary syndrome (PCOS) is characterized by an oligo-anovulation, hyperandrogenism and polycystic ovarian morphology combined with major metabolic disturbances. However, despite the high prevalence and the human and economic consequences of this syndrome, its etiology remains unknown. In this study, we show that female Goto-Kakizaki (GK) rats, a type 2 diabetes mellitus model, encapsulate naturally all...

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Identifiers

PMID: 33594056
DOI: 10.1038/s41467-021-21308-y
PMCID: PMC7886868

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