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Article

Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus.

Current biology : CB - 5 Jan 2015

Zheng He, Kim Jaekuk, Liew Mathew, Yan John K, Herrera Oscar, Bok Jin Woo, Kelleher Neil L, Keller Nancy P, Wang Yun

Abstract excerpt

BACKGROUND: Filamentous fungi and bacteria form mixed-species biofilms in nature and diverse clinical contexts. They secrete a wealth of redox-active small molecule secondary metabolites, which are traditionally viewed as toxins that inhibit growth of competing microbes. RESULTS: Here, we report that these "toxins" can act as interspecies signals, affecting filamentous fungal development via oxidative stress...

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Identifiers

PMID: 25532893
DOI: 10.1016/j.cub.2014.11.018
PMCID: PMC4286458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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