Article
Activating cysteinyl leukotriene receptor 2 (CYSLTR2) mutations in blue nevi.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2017
Möller Inga, Murali Rajmohan, Müller Hansgeorg, Wiesner Thomas, Jackett Louise A, Scholz Simone L, Cosgarea Ioana, van de Nes Johannes Ap, Sucker Antje, Hillen Uwe, Schilling Bastian, Paschen Annette, Kutzner Heinz, Rütten Arno, Böckers Martin, Scolyer Richard A, Schadendorf Dirk, Griewank Klaus G
Abstract excerpt
Blue nevi are common melanocytic tumors arising in the dermal layer of the skin. Similar to uveal melanomas, blue nevi frequently harbor GNAQ and GNA11 mutations. Recently, recurrent CYSLTR2 and PLCB4 mutations were identified in uveal melanomas not harboring GNAQ or GNA11 mutations. All four genes (GNAQ, GNA11, CYSLTR2, and PLCB4) code for proteins involved in the same signaling pathway, which is activated by...
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