Article

Contribution of genetic and environmental factors to the onset of preclinical Alzheimer’s disease - a monozygotic twin study

2020-06-14

Abstract excerpt

<h4>Objective</h4> To study the genetic contribution to the start of Alzheimer’s disease as signified by abnormalities in amyloid and tau biomarkers in cognitively intact older identical twins. <h4>Methods</h4> We studied in 96 monozygotic twin-pairs relationships between Aβ aggregation as measured by the ratio Aβ1-42/1-40 in cerebrospinal fluid (CSF) and positron emission tomography (PET), and CSF markers for Aβ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fc3e354-b8c7-5e8e-8035-25d33f911794
DOI: 10.1101/2020.06.12.20129346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contribution of genetic and environmental factors to the onset of preclinical Alzheimer’s disease - a monozygotic twin studyDOI 10.1101/2020.06.12.20129346Read

Onset of Preclinical Alzheimer Disease in Monozygotic Twins.Semantic proximity Read

Twin study shows that genetic factors influence the development and timing of Alzheimer’s diseaseSemantic proximity Read

Role of genes and environments for explaining Alzheimer disease.Semantic proximity Read

Genetically identical twin-pair difference models support the amyloid cascade hypothesisSemantic proximity Read

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twinsSemantic proximity Read

Plasma biomarkers predict amyloid conversion and cognitive decline in cognitively unimpaired adultsSemantic proximity Read

Abnormal cerebrospinal fluid levels of amyloid and tau are associated with cognitive decline over time in cognitively normal older adults: A monozygotic twin studySemantic proximity Read

Heritability for Alzheimer's Disease: The Study of Dementia in Swedish TwinsSemantic proximity Read

Genetic architecture of Alzheimer’s disease-related plasma biomarkersSemantic proximity Read

A Twin Study of Sex Differences in Genetic Risk for All Dementia, Alzheimer's Disease (AD), and Non-AD Dementia.Semantic proximity Read

Genetically identical twins show comparable tau PET load and spatial distributionSemantic proximity Read

Shared genetic background between cerebrospinal fluid biomarkers and risk for Alzheimer’s disease: A two-sample Mendelian randomisation studySemantic proximity Read