Article
ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.
Molecular cancer therapeutics - 1 Apr 2015
Wang Shu, Chen Xiangyun Amy, Hu Jing, Jiang Jian-Kang, Li Yunfei, Chan-Salis Ka Yim, Gu Ying, Chen Gong, Thomas Craig, Pugh B Franklin, Wang Yanming
Abstract excerpt
We previously reported that a pan-PAD inhibitor, YW3-56, activates p53 target genes to inhibit cancer growth. However, the p53-independent anticancer activity and molecular mechanisms of YW3-56 remain largely elusive. Here, gene expression analyses found that ATF4 target genes involved in endoplasmic reticulum (ER) stress response were activated by YW3-56. Depletion of ATF4 greatly attenuated YW3-56-mediated...
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