Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme.

doi:10.1186/s12872-021-01860-7

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Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme.

BMC cardiovascular disorders - 12 Feb 2021

Watson Chris, Spiers J Paul, Waterstone Max, Russell-Hallinan Adam, Gallagher Joseph, McDonald Kenneth, Ryan Cristin, Gilmer John, Ledwidge Mark

Abstract excerpt

BACKGROUND: Hypertension and/or myocardial infarction are common causes of heart failure in Type 2 diabetes. Progression to heart failure is usually preceded by ventricular dysfunction, linked to matrix metalloproteinase (MMP) mediated extracellular matrix changes. We hypothesise that the minor allele of genetic variant rs3918242 in the promoter region of the MMP-9 gene is associated with hypertension and/or...

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PMID: 33579197
DOI: 10.1186/s12872-021-01860-7
PMCID: PMC7879511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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