Article
Association of the beta-1 adrenergic receptor carboxyl terminal variants with left ventricular hypertrophy among diabetic and non-diabetic survivors of acute myocardial infarction.
Cardiovascular diabetology - 23 Aug 2010
Hakalahti Anna E, Tapanainen Jari M, Junttila Juhani M, Kaikkonen Kari S, Huikuri Heikki V, Petäjä-Repo Ulla E
Abstract excerpt
BACKGROUND: The beta-1 adrenergic receptor (beta1AR) plays a fundamental role in the regulation of cardiovascular functions. It carries a nonsynonymous single nucleotide polymorphism in its carboxyl terminal tail (Arg389Gly), which has been shown to associate with various echocardiographic parameters linked to left ventricular hypertrophy (LVH). Diabetes mellitus (DM), on the other hand, represents a risk factor...
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