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Article

Constitutive activity of GPR26 regulated by ubiquitin-dependent degradation and its antitumor role.

The FEBS journal - 1 Aug 2021

Liu Fang, Yang Wei, Hu Minghui, Zhang Yong, Sun Beicheng, Yang Hao, Brosius Juergen, Deng Cheng

Abstract excerpt

G protein-coupled receptors (GPCRs) play important roles in many physiological functions and numerous diseases. In addition to the classic ligand-stimulated receptor activity, an increasing number of studies have established that many GPCRs function constitutively in a receptor dose-dependent manner. Previous observations showed that following gene transfection, little or no protein was detectable for certain...

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Identifiers

PMID: 33577134
DOI: 10.1111/febs.15763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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