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Article

PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung.

Cancer immunology, immunotherapy : CII - 1 Sept 2021

Goldmann Torsten, Marwitz Sebastian, Nitschkowski Dörte, Krupar Rosemarie, Backman Max, Elfving Hedvig, Thurfjell Viktoria, Lindberg Amanda, Brunnström Hans, La Fleur Linnea, Mezheyeuski Artur, Mattsson Johanna Sofia Margareta, Botling Johan, Micke Patrick, Strell Carina

Abstract excerpt

Gene amplification is considered to be one responsible cause for upregulation of Programmed Death Ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) and to represent a specific molecular subgroup possibly associated with immunotherapy response. Our aim was to analyze the frequency of PD-L1 amplification, its relation to PD-L1 mRNA and protein expression, and to characterize the immune microenvironment of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33576873
DOI: 10.1007/s00262-020-02825-z
PMCID: PMC8360842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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