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Article

Signs of Deregulated Gene Expression Are Present in Both CD14+ and CD14- PBMC From Non-Obese Men With Family History of T2DM.

Frontiers in endocrinology - 1 Jan 2020

Koc Michal, Šiklová Michaela, Šrámková Veronika, Štěpán Marek, Krauzová Eva, Štich Vladimír, Rossmeislová Lenka

Abstract excerpt

Aim: Development of type 2 diabetes (T2DM) is associated with disturbances in immune and metabolic status that may be reflected by an altered gene expression profile of peripheral blood mononuclear cells (PBMC). To reveal a potential family predisposition to these alterations, we investigated the regulation of gene expression profiles in circulating CD14+ and CD14- PBMC in fasting conditions and in response to...

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Biomarkers
Blood Glucose
Diabetes Mellitus, Type 2
Gene Expression Regulation
Glucose Tolerance Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Lipopolysaccharide Receptors

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Identifiers

PMID: 33658980
DOI: 10.3389/fendo.2020.582732
PMCID: PMC7917286

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