Article
Assembly and Analysis of Unmapped Genome Sequence Reads Reveal Novel Sequence and Variation in Dogs.
Scientific reports - 18 Jul 2018
Holden Lindsay A, Arumilli Meharji, Hytönen Marjo K, Hundi Sruthi, Salojärvi Jarkko, Brown Kim H, Lohi Hannes
Abstract excerpt
Dogs are excellent animal models for human disease. They have extensive veterinary histories, pedigrees, and a unique genetic system due to breeding practices. Despite these advantages, one factor limiting their usefulness is the canine genome reference (CGR) which was assembled using a single purebred Boxer. Although a common practice, this results in many high-quality reads remaining unmapped. To address this...
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