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Article

Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.

Diabetes - 1 Dec 2002

Schwanstecher Christina, Schwanstecher Mathias

Abstract excerpt

Type 2 diabetes is generally perceived as a polygenic disorder, with disease development being influenced by both hereditary and environmental factors. However, despite intensive investigations, little progress has been made in identifying the genes that impart susceptibility to the common late-o...

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Share to Adenosine Triphosphate
Share to Diabetes Mellitus, Type 2
Share to Nucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pancreas

Share to Pancreatic function and diabetes

Share to Polymorphism, Single Nucleotide

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Source

Identifiers

PMID: 12475775
DOI: 10.2337/diabetes.51.2007.s358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12475775-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.PMID 12475775Read ↗

The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates.Semantic proximity Read ↗

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.Semantic proximity Read ↗

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.Semantic proximity Read ↗

Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes.Semantic proximity Read ↗

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.Semantic proximity Read ↗

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