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Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.

Diabetes - 1 Dec 2002

Schwanstecher Christina, Schwanstecher Mathias

Abstract excerpt

Type 2 diabetes is generally perceived as a polygenic disorder, with disease development being influenced by both hereditary and environmental factors. However, despite intensive investigations, little progress has been made in identifying the genes that impart susceptibility to the common late-onset forms of the disease. E23K, a common single nucleotide polymorphism in K(IR)6.2, the pore-forming subunit of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12475775
DOI: 10.2337/diabetes.51.2007.s358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes.PMID 12475775Read ↗

The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates.Semantic proximity Read ↗

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels.Semantic proximity Read ↗

An E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARγ Pro12Ala variantSemantic proximity Read ↗

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.Semantic proximity Read ↗

Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.Semantic proximity Read ↗

ATP-dependent potassium channels and type 2 diabetes mellitus.Semantic proximity Read ↗

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.Semantic proximity Read ↗

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.Semantic proximity Read ↗

Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes.Semantic proximity Read ↗

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.Semantic proximity Read ↗

ATP-sensitive potassium channels in health and disease.Semantic proximity Read ↗

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.Semantic proximity Read ↗

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