Article
Plasticity of the Influenza Virus H5 HA Protein.
mBio - 9 Feb 2021
Kong Huihui, Burke David F, da Silva Lopes Tiago Jose, Takada Kosuke, Imai Masaki, Zhong Gongxun, Hatta Masato, Fan Shufang, Chiba Shiho, Smith Derek, Neumann Gabriele, Kawaoka Yoshihiro
Abstract excerpt
Since the emergence of highly pathogenic avian influenza viruses of the H5 subtype, the major viral antigen, hemagglutinin (HA), has undergone constant evolution, resulting in numerous genetic and antigenic (sub)clades. To explore the consequences of amino acid changes at sites that may affect the antigenicity of H5 viruses, we simultaneously mutated 17 amino acid positions of an H5 HA by using a synthetic gene...
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