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Article

Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages.

International immunopharmacology - 1 Apr 2021

Jiang Chaolai, Zhou Zubin, Lin Yiwei, Shan Haojie, Xia Wenyang, Yin Fuli, Wang Nan, Zhou Lihui, Gao Youshui, Yu Xiaowei

Abstract excerpt

Osteonecrosis of the femoral head (ON-FH) is a common complication of steroid use. Pro-inflammatory macrophages play a crucial role in the apoptosis of osteocytes. The objective of the study was to evaluate a plant extract astragaloside IV (AS-IV) in treating ON-FN. Bone-marrow-derived macrophages (BMDMs) were treated with lipopolysaccharides (LPS), IFN-γ or IL-4 to induce M1 and M2-like phenotypes. Quantitative...

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Identifiers

PMID: 33563553
DOI: 10.1016/j.intimp.2020.107345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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