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A theoretical and generalized approach for the assessment of the sample-specific limit of detection for clinical metagenomics

26 Dec 2020

Abstract excerpt

Metagenomics is a powerful tool to identify novel or unexpected pathogens, since it is generic and relatively unbiased. The limit of detection (LOD) is a critical parameter for the routine application of methods in the clinical diagnostic context. Although attempts for the determination of LODs for metagenomics next-generation sequencing (mNGS) have been made previously, these were only applicable for specific...

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PMID: 33552445
DOI: 10.1016/j.csbj.2020.12.040

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