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RNA-Seq Reveals Differences in Expressed Tumor Mutation Burden in Colorectal and Endometrial Cancers with and without Defective DNA-Mismatch Repair.

The Journal of molecular diagnostics : JMD - 1 May 2021

DiGuardo Margaret A, Davila Jaime I, Jackson Rory A, Nair Asha A, Fadra Numrah, Minn Kay T, Atiq Mazen A, Zarei Shabnam, Blommel Joseph H, Knight Shannon M, Jen Jin, Eckloff Bruce W, Voss Jesse S, Rumilla Kandelaria M, Kerr Sarah E, Lam-Himlin Dora M, Bellizzi Andrew M, Graham Rondell P, Kipp Benjamin R, Jenkins Robert B, Halling Kevin C

Abstract excerpt

Tumor mutation burden (TMB) is an emerging biomarker of immunotherapy response. RNA sequencing in FFPE tissue samples was used for determining TMB in microsatellite-stable (MSS) and microsatellite instability-high (MSI-H) tumors in patients with colorectal or endometrial cancer. Tissue from tumors and paired normal tissue from 46 MSI-H and 12 MSS cases were included. Of the MSI-H tumors, 29 had defective DNA...

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Aged, 80 and over
Biomarkers, Tumor
Colorectal Neoplasms
DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Endometrial Neoplasms

Follow-Up Studies

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PMID: 33549857
DOI: 10.1016/j.jmoldx.2021.01.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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