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Article

Gender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility.

Journal of translational medicine - 6 Feb 2021

Benna Clara, Rajendran Senthilkumar, Spiro Giovanna, Menin Chiara, Dall'Olmo Luigi, Rossi Carlo Riccardo, Mocellin Simone

Abstract excerpt

BACKGROUND: Melanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ultraviolet light. Genetic variability of the components of the biological circadian clock is recognized to be a risk factor for different type of cancers. Moreover, two variants of a clock gene,...

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Alleles
Circadian Rhythm
Genetic Predisposition to Disease
Melanoma
Nuclear Receptor Subfamily 1, Group F, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 33549124
DOI: 10.1186/s12967-021-02725-5
PMCID: PMC7866430

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