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DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models

23 May 2025

Abstract excerpt

PURPOSE: To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies. RECENT FINDINGS: Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA...

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PMID: 40407877
DOI: 10.1007/s00404-025-08048-w

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