Article
Co-ordinated ocular development from human iPS cells and recovery of corneal function.
Nature - 17 Mar 2016
Hayashi Ryuhei, Ishikawa Yuki, Sasamoto Yuzuru, Katori Ryosuke, Nomura Naoki, Ichikawa Tatsuya, Araki Saori, Soma Takeshi, Kawasaki Satoshi, Sekiguchi Kiyotoshi, Quantock Andrew J, Tsujikawa Motokazu, Nishida Kohji
Abstract excerpt
The eye is a complex organ with highly specialized constituent tissues derived from different primordial cell lineages. The retina, for example, develops from neuroectoderm via the optic vesicle, the corneal epithelium is descended from surface ectoderm, while the iris and collagen-rich stroma of the cornea have a neural crest origin. Recent work with pluripotent stem cells in culture has revealed a previously...
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