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Article

Patients With LDLR and PCSK9 Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia.

Journal of the American Heart Association - 16 Feb 2021

Doi Takahito, Hori Mika, Harada-Shiba Mariko, Kataoka Yu, Onozuka Daisuke, Nishimura Kunihiro, Nishikawa Ryo, Tsuda Kosuke, Ogura Masatsune, Son Cheol, Miyamoto Yoshihiro, Noguchi Teruo, Shimokawa Hiroaki, Yasuda Satoshi

Abstract excerpt

Background Patients with familial hypercholesterolemia who harbored both low-density lipoprotein receptor (LDLR) and PCSK9 (proprotein convertase subtilisin/kexin type 9) gene variants exhibit severe phenotype associated with substantially high levels of low-density lipoprotein cholesterol. In this study, we investigated the cardiovascular outcomes in patients with both LDLR and PCSK9 gene variants. Methods and...

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Identifiers

PMID: 33533259
DOI: 10.1161/JAHA.120.018263
PMCID: PMC7955325

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