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Article

Interactive effects of genotype with prenatal stress on DNA methylation at birth.

Molecular psychiatry - 1 Dec 2025

Mulder Rosa H, Baltramonaityte Vilte, Defina Serena, Trajanoska Katerina, Suderman Matthew, Schwarz Emanuel, Boks Marco P M, Walton Esther, Cecil Charlotte A M, Felix Janine F

Abstract excerpt

Intrauterine stress exposure is associated with offspring health. DNA methylation (DNAm) is a putative underlying mechanism, but large population-based studies reported limited associations between prenatal stress and DNAm. Recent research has shown that environmental factors in interaction with genetic variants are better predictors of DNAm than environment or genotype alone. We investigated whether interactions...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41136745
DOI: 10.1038/s41380-025-03312-6
PMCID: PMC12602324

Genes

AHRR
CHD2
EPPK1
GFI1
MYO1G
ORC5

Provenance

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