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Recurrent genetic fusions redefine MLL germ line acute lymphoblastic leukemia in infants

22 Dec 2020

Abstract excerpt

B-cell precursor (BCP) acute lymphoblastic leukemia (BCP-ALL) in infants (ie, children age <1 year) is a rare disease traditionally subdivided into MLL-rearranged (alias KMT2A; MLL-R) and MLL germ line (MLL-G) subtypes. MLL gene rearrangements occur in ∼75% of infants with BCP-ALL1-3 and are typically associated with a mixed-lineage phenotype.4 MLL rearrangements originate prenatally in utero5 and play a role in...

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PMID: 33512459
DOI: 10.1182/blood.2020009032

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