Article
Innocuous pressure sensation requires A-type afferents but not functional ΡΙΕΖΟ2 channels in humans.
Nature communications - 28 Jan 2021
Case Laura K, Liljencrantz Jaquette, Madian Nicholas, Necaise Aaron, Tubbs Justin, McCall Micaela, Bradson Megan L, Szczot Marcin, Pitcher Mark H, Ghitani Nima, Frangos Eleni, Cole Jonathan, Bharucha-Goebel Diana, Saade Dimah, Ogata Tracy, Donkervoort Sandra, Foley A Reghan, Bönnemann Carsten G, Olausson Håkan, Bushnell M Catherine, Chesler Alexander T
Abstract excerpt
The sensation of pressure allows us to feel sustained compression and body strain. While our understanding of cutaneous touch has grown significantly in recent years, how deep tissue sensations are detected remains less clear. Here, we use quantitative sensory evaluations of patients with rare sensory disorders, as well as nerve blocks in typical individuals, to probe the neural and genetic mechanisms for...
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