Article
Identification of Variants (rs11571707, rs144848, and rs11571769) in the BRCA2 Gene Associated with Hereditary Breast Cancer in Indigenous Populations of the Brazilian Amazon.
Genes - 22 Jan 2021
Dobbin Elizabeth Ayres Fragoso, Medeiros Jéssyca Amanda Gomes, Costa Marta Solange Camarinha Ramos, Rodrigues Juliana Carla Gomes, Guerreiro João Farias, Kroll José Eduardo, Souza Sandro José de, de Assumpção Paulo Pimentel, Ribeiro-Dos-Santos Ândrea, Santos Sidney Emanuel Batista Dos, Burbano Rommel Mario Rodríguez, Fernandes Marianne Rodrigues, Santos Ney Pereira Carneiro Dos
Abstract excerpt
Estimates show that 5-10% of breast cancer cases are hereditary, caused by genetic variants in autosomal dominant genes; of these, 16% are due to germline mutations in the BRCA1 and BRCA2 genes. The comprehension of the mutation profile of these genes in the Brazilian population, particularly in Amazonian Amerindian groups, is scarce. We investigated fifteen polymorphisms in the BRCA1 and BRCA2 genes in Amazonian...
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