Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry.

Oncotarget - 6 Dec 2016

Fernandes Gabriela C, Michelli Rodrigo A D, Galvão Henrique C R, Paula André E, Pereira Rui, Andrade Carlos E, Felicio Paula S, Souza Cristiano P, Mendes Deise R P, Volc Sahlua, Berardinelli Gustavo N, Grasel Rebeca S, Sabato Cristina S, Viana Danilo V, Mauad Edmundo C, Scapulatempo-Neto Cristovam, Arun Banu, Reis Rui M, Palmero Edenir I

Abstract excerpt

BACKGROUND: There are very few data about the mutational profile of families at-risk for hereditary breast and ovarian cancer (HBOC) from Latin America (LA) and especially from Brazil, the largest and most populated country in LA. RESULTS: Of the 349 probands analyzed, 21.5% were BRCA1/BRCA2 mutated, 65.3% at BRCA1 and 34.7% at BRCA2 gene. The mutation c.5266dupC (former 5382insC) was the most frequent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brazil
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Germ-Line Mutation

Share to Heredity

Share to Inheritance Patterns

Share to Ovarian Neoplasms

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 27741520
DOI: 10.18632/oncotarget.12610
PMCID: PMC5348334

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry.PMID 27741520Read ↗

BRCA1 and BRCA2 germline mutation analysis from a cohort of 1267 patients at high risk for breast cancer in Brazil.Semantic proximity Read ↗

Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil.Semantic proximity Read ↗

Germline mutations in BRCA1, BRCA2, CHEK2 and TP53 in patients at high-risk for HBOC: characterizing a Northeast Brazilian PopulationSemantic proximity Read ↗

Hereditary breast cancer next-generation sequencing (NGS) panel evaluation in the south region of Brazil: a novel<i>BRCA2</i>candidate pathogenic variant is reportedSemantic proximity Read ↗

BRCA1 and BRCA2 mutational profile and prevalence in hereditary breast and ovarian cancer (HBOC) probands from Southern Brazil: Are international testing criteria appropriate for this specific population?Semantic proximity Read ↗

Systematic review of the molecular basis of hereditary breast and ovarian cancer syndrome in Brazil: the current scenario.Semantic proximity Read ↗

The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective.Semantic proximity Read ↗

Prevalence of Hispanic BRCA1 and BRCA2 mutations among hereditary breast and ovarian cancer patients from Brazil reveals differences among Latin American populations.Semantic proximity Read ↗

Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in BrazilSemantic proximity Read ↗

A portrait of germline mutation in Brazilian at-risk for hereditary breast cancer.Semantic proximity Read ↗

The role of targeted BRCA1/BRCA2 mutation analysis in hereditary breast/ovarian cancer families of Portuguese ancestry.Semantic proximity Read ↗

Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern BrazilSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.