Article
DNA methylation perturbations may link altered development and aging in the lung.
Aging - 19 Jan 2021
Kachroo Priyadarshini, Morrow Jarrett D, Vyhlidal Carrie A, Gaedigk Roger, Silverman Edwin K, Weiss Scott T, Tantisira Kelan G, DeMeo Dawn L
Abstract excerpt
Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 exposed to in-utero-smoke (IUS)) tissue and chronological age in adult-lung tissue (n=160, 114 with...
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