Article
DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life.
International journal of molecular sciences - 14 Jan 2021
Acevedo Nathalie, Scala Giovanni, Merid Simon Kebede, Frumento Paolo, Bruhn Sören, Andersson Anna, Ogris Christoph, Bottai Matteo, Pershagen Göran, Koppelman Gerard H, Melén Erik, Sonnhammer Erik, Alm Johan, Söderhäll Cilla, Kere Juha, Greco Dario, Scheynius Annika
Abstract excerpt
DNA methylation changes may predispose becoming IgE-sensitized to allergens. We analyzed whether DNA methylation in peripheral blood mononuclear cells (PBMC) is associated with IgE sensitization at 5 years of age (5Y). DNA methylation was measured in 288 PBMC samples from 74 mother/child pairs from the birth cohort ALADDIN (Assessment of Lifestyle and Allergic Disease During INfancy) using the...
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