Article
Epigenetic regulation: the interface between prenatal and early-life exposure and asthma susceptibility.
Environmental and molecular mutagenesis - 1 Apr 2014
de Planell-Saguer Mariàngels, Lovinsky-Desir Stephanie, Miller Rachel L
Abstract excerpt
Asthma is a complex disease with genetic and environmental influences and emerging evidence suggests that epigenetic regulation is also a major contributor. Here, we focus on the developing paradigm that epigenetic dysregulation in asthma and allergy may start as early as in utero following several environmental exposures. We summarize the pathways important to the allergic immune response that are epigenetically...
Topics
- Adolescent
- Antigen Presentation
- Asthma
- Biomarkers
- Child
- Child, Preschool
- Dendritic Cells
- Environmental Exposure
- Epigenesis, Genetic
- Female
- Gene Expression Regulation, Developmental