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Arabidopsis sirtuins and poly(ADP-ribose) polymerases regulate gene expression in the day but do not affect circadian rhythms.

Plant, cell & environment - 1 May 2021

Kim Jun Hyeok, Bell Laura J, Wang Xiao, Wimalasekera Rinuckshi, Bastos Hugo P, Kelly Krystyna A, Hannah Matthew A, Webb Alex A R

Abstract excerpt

Nicotinamide-adenine dinucleotide (NAD) is involved in redox homeostasis and acts as a substrate for NADases, including poly(ADP-ribose) polymerases (PARPs) that add poly(ADP-ribose) polymers to proteins and DNA, and sirtuins that deacetylate proteins. Nicotinamide, a by-product of NADases increases circadian period in both plants and animals. In mammals, the effect of nicotinamide on circadian period might be...

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PMID: 33464569
DOI: 10.1111/pce.13996

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