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Article

TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy

23 Aug 2011

Abstract excerpt

The autophagic pathway participates in many physiological and pathophysiological processes. Autophagy plays an important role, as part of the innate immune response, in the first line of defense against intruding pathogens. Recognition of pathogens by the autophagic machinery is mainly mediated by autophagic adaptors, proteins that simultaneously interact with specific cargos and components of the autophagic...

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PMID: 21868362
DOI: 10.1126/scisignal.2002355

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