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Article

Meta-analysis of sample-level dbGaP data reveals novel shared genetic link between body height and Crohn's disease.

Human genetics - 1 Jun 2021

Di Narzo Antonio, Frades Itziar, Crane Heidi M, Crane Paul K, Hulot Jean-Sebastian, Kasarskis Andrew, Hart Amy, Argmann Carmen, Dubinsky Marla, Peter Inga, Hao Ke

Abstract excerpt

To further explore genetic links between complex traits, we developed a comprehensive framework to harmonize and integrate extensive genotype and phenotype data from the four well-characterized cohorts with the focus on cardiometabolic diseases deposited to the database of Genotypes and Phenotypes (dbGaP). We generated a series of polygenic risk scores (PRS) to investigate pleiotropic effects of loci that confer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33452914
DOI: 10.1007/s00439-020-02250-3
PMCID: PMC8102349

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