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Article

Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease.

Scientific reports - 15 Jan 2021

Matsuo Muneaki, Nadanaka Satomi, Soga Minami, Sugiyama Taku, Serigano Shota, Shimano Kenjiro, Ichinose Fumio, Nakamura Takuji, Maeda Toshiyuki, Houkin Kiyohiro, Era Takumi, Kitagawa Hiroshi

Abstract excerpt

Moyamoya disease (MMD) is characterized by progressive bilateral stenotic changes in the terminal portion of the internal carotid arteries. Although RNF213 was identified as a susceptibility gene for MMD, the exact pathogenesis remains unknown. Immunohistochemical analysis of autopsy specimens from a patient with MMD revealed marked accumulation of hyaluronan and chondroitin sulfate (CS) in the thickened intima...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33452387
DOI: 10.1038/s41598-021-81282-9
PMCID: PMC7810726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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