Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.

Abstract excerpt

BACKGROUND: Transfusion dependent thalassemia (TDT) patients are treated with continued blood transfusions and show a higher prevalence of depression. TDT with consequent iron overload and inflammation is associated with increased severity of depressive symptoms in TDT children. AIM OF THE STUDY: To construct a pathway-phenotype which combines iron overload and neuro-immune biomarkers with depressive symptom...

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