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Article

Functional refolding of the penetration protein on a non-enveloped virus.

Nature - 1 Feb 2021

Herrmann Tobias, Torres Raúl, Salgado Eric N, Berciu Cristina, Stoddard Daniel, Nicastro Daniela, Jenni Simon, Harrison Stephen C

Abstract excerpt

A non-enveloped virus requires a membrane lesion to deliver its genome into a target cell1. For rotaviruses, membrane perforation is a principal function of the viral outer-layer protein, VP42,3. Here we describe the use of electron cryomicroscopy to determine how VP4 performs this function and show that when activated by cleavage to VP8* and VP5*, VP4 can rearrange on the virion surface from an 'upright' to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33442061
DOI: 10.1038/s41586-020-03124-4
PMCID: PMC8297411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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