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Article

High expression of hypoxia inducible factor 1α related with acquired resistant to EGFR tyrosine kinase inhibitors in NSCLC.

Scientific reports - 13 Jan 2021

Jin Qian, Huang Feihua, Xu Xianrong, He Haidong, Zhang Yingqing

Abstract excerpt

The acquired resistance of the first generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is a main factor leading to poor prognosis of non-small cell lung cancer (NSCLC), so we researched whether the high expression of hypoxia-inducible factor-1α (HIF-1α) in EGFR-TKIs sensitive NSCLC tissue tends to induce the acquired resistance. We detected the HIF-1α in normal lung tissue,...

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Identifiers

PMID: 33441708
DOI: 10.1038/s41598-020-79801-1
PMCID: PMC7806909

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