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Immunomodulation of ovarian cancer by DNMTi and expression of endogenous retroviruses

2020-01-01

Abstract excerpt

Immunotherapeutic strategies for ovarian cancer (OC) patients have so far failed to show any benefit in clinical trials. Novel combination strategies are being developed to enhance immune function in these patients by overcoming immunosuppressive mechanisms present within the ovarian tumour microenvironment. Epigenetic modifying agents, such as DNA methyltransferase inhibitors (DNMTi), have shown some promise in s...

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Literature Corpus work
e0ba2173-99e0-537b-bd0f-99a5b76a026c
DOI
10.25560/89688
Open publication

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