Article
Exemplar scoring identifies genetically separable phenotypes of lithium responsive bipolar disorder.
Translational psychiatry - 11 Jan 2021
Nunes Abraham, Stone William, Ardau Raffaella, Berghöfer Anne, Bocchetta Alberto, Chillotti Caterina, Deiana Valeria, Degenhardt Franziska, Forstner Andreas J, Garnham Julie S, Grof Eva, Hajek Tomas, Manchia Mirko, Mattheisen Manuel, McMahon Francis, Müller-Oerlinghausen Bruno, Nöthen Markus M, Pinna Marco, Pisanu Claudia, O'Donovan Claire, Rietschel Marcella D C, Rouleau Guy, Schulze Thomas, Severino Giovanni, Slaney Claire M, Squassina Alessio, Suwalska Aleksandra, Turecki Gustavo, Uher Rudolf, Zvolsky Petr, Cervantes Pablo, Del Zompo Maria, Grof Paul, Rybakowski Janusz, Tondo Leonardo, Trappenberg Thomas, Alda Martin
Abstract excerpt
Predicting lithium response (LiR) in bipolar disorder (BD) may inform treatment planning, but phenotypic heterogeneity complicates discovery of genomic markers. We hypothesized that patients with "exemplary phenotypes"-those whose clinical features are reliably associated with LiR and non-response (LiNR)-are more genetically separable than those with less exemplary phenotypes. Using clinical data collected from...
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