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Article

Generation and Characterization of Recombinant SARS-CoV-2 Expressing Reporter Genes

12 Jan 2021

Abstract excerpt

Importantly, reporter-expressing rSARS-CoV-2 display similar growth kinetics and plaque phenotype that their wild-type counterpart (rSARS-CoV-2/WT), demonstrating their feasibility to identify drugs and/or neutralizing antibodies (NAbs) for the therapeutic treatment of SARS-CoV-2. Henceforth, these reporter-expressing rSARS-CoV-2 can be used to interrogate large libraries of compounds and/or monoclonal antibodies...

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PMID: 33431557
DOI: 10.1128/jvi.02209-20

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