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Evaluation of enzymatic activity of Babesia microti thioredoxin reductase (Bmi TrxR)-mutants and screening of its potential inhibitors.

Ticks and tick-borne diseases - 1 Mar 2021

Lu Jinmiao, Wei Nana, Cao Jie, Zhou Yongzhi, Gong Haiyan, Zhang Houshuang, Zhou Jinlin

Abstract excerpt

Babesia microti is a zoonotic pathogen that mainly parasitizes mammalian erythrocytes. Oxidative stress can induce gene mutation, protein denaturation and lipid peroxidation, such as reactive oxygen species (ROS) induced by hypoxic environment and the host immune system. An antioxidase, B. microti thioredoxin reductase (Bmi TrxR), has been identified in B. microti. We used a combination of homology modeling and...

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PMID: 33418338
DOI: 10.1016/j.ttbdis.2020.101623

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