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Article

Phosphorylation of Influenza A Virus NS1 at Serine 205 Mediates Its Viral Polymerase-Enhancing Function.

Journal of virology - 24 Feb 2021

Patil Amol, Anhlan Darisuren, Ferrando Verónica, Mecate-Zambrano Angeles, Mellmann Alexander, Wixler Viktor, Boergeling Yvonne, Ludwig Stephan

Abstract excerpt

Influenza A virus (IAV) nonstructural protein 1 (NS1) is a protein with multiple functions that are regulated by phosphorylation. Phosphoproteomic screening of H1N1 virus-infected cells revealed that NS1 was phosphorylated at serine 205 in intermediate stages of the viral life cycle. Interestingly, S205 is one of six amino acid changes in NS1 of post-pandemic H1N1 viruses currently circulating in humans compared...

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Identifiers

PMID: 33408177
DOI: 10.1128/JVI.02369-20
PMCID: PMC8094967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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