Article
Association of three missense mutations in the homocysteine-related MTHFR and MTRR gene with risk of polycystic ovary syndrome in Southern Chinese women.
Reproductive biology and endocrinology : RB&E - 7 Jan 2021
Feng Wanqin, Zhang Yan, Pan Yuan, Zhang Yi, Liu Minjuan, Huang Yuxin, Xiao Yuanling, Mo Wenyu, Jiao Junjie, Wang Xiaoyang, Tian Dan, Yang Lixia, Ma Ying
Abstract excerpt
BACKGROUND: The etiology between homocysteine and polycystic ovary syndrome (PCOS) is unclear. In humans, the level of homocysteine is mainly affected by two enzymes: methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR). While the activity of these two enzymes is mainly affected by three missense mutations, namely C677T (MTHFR), A1298C (MTHFR), and A66G (MTRR). This study aims to...
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