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Article

An Unusual Pattern of Premature Cervical Spine Degeneration in STAT3-LOF.

Journal of clinical immunology - 1 Apr 2021

Mitchell Amelia L, Urban Amanda K, Freeman Alexandra F, Hammoud Dima A

Abstract excerpt

Loss of function mutations in STAT3 (STAT3-LOF; autosomal dominant hyper-IgE (Job's) syndrome) are associated with a variety of musculoskeletal manifestations, including scoliosis, osteoporosis, and minimal trauma fractures. This retrospective magnetic resonance (MR) imaging study sought to characterize an unusual pattern of cervical spine degeneration among a cohort of STAT3-LOF patients. Cervical spine MR...

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Source

Identifiers

PMID: 33404973
DOI: 10.1007/s10875-020-00926-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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