Article
Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9.
Scientific reports - 9 Jun 2017
Guo Dongsheng, Liu Haikun, Ruzi Aynisahan, Gao Ge, Nasir Abbas, Liu Yanli, Yang Fan, Wu Feima, Xu Guosheng, Li Yin-Xiong
Abstract excerpt
Congenital hyperinsulinism (CHI) is a rare genetic disorder characterized by excess insulin secretion, which results in hypoglycemia. Mutation of sulfonylurea receptor 1 (SUR1), encoded by the ABCC8 gene, is the main cause of CHI. Here, we captured the phenotype of excess insulin secretion through pancreatic differentiation of ABCC8-deficient stem cells generated by the CRISPR/Cas9 system. ABCC8-deficient...
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