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Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering

30 Dec 2020

Abstract excerpt

The development of effective and safe vaccines is the ultimate way to efficiently stop the ongoing COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Built on the fact that SARS-CoV-2 utilizes the association of its Spike (S) protein with the human angiotensin-converting enzyme 2 (ACE2) receptor to invade host cells, we computationally redesigned the S protein...

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PMID: 33398234
DOI: 10.1016/j.csbj.2020.12.039

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